Rotavirus vaccine risk intussusception. Risk Factors for Infant Intussusception After Introduction of Rotavirus Vaccine

(PDF) Rotavirus vaccines and intussusception risk

rotavirus vaccine risk intussusception

These findings are preliminary, as the data are subject to confirmation. Exposure windows examined were exposure to first rotavirus vaccine dose in the first 7 days and 14 days prior to intussusception occurrence. Incorporation of this vaccine into routine immunisation schedules of infants could reduce severe rotavirus gastroenteritis by 90% and severe gastroenteritis of all causes in young children by 60%. For children under 5 years of age in developing areas and countries, there was a median of 3. Our study showed that hypergastrinemia may be the basis etiologic factor of intussusception.

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(PDF) Rotavirus vaccines and intussusception risk

rotavirus vaccine risk intussusception

The data were de-identified prior to analysis. Several new rotavirus vaccines have been developed and have proven to be safe and efficacious. Light microscopic examination showed viral inclusions in 19 of the appendices from the cases of intussusception and in none of the controls. A series of 39 appendices from cases of intussusception and 15 control appendices were reviewed. The risk is highest during the 3 to 14 days following receipt of the first dose of vaccine. Results were pooled using the inverse variance method using both fixed-effect and random-effect models.

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Intussusception: A Very Rare Risk After Rotavirus Vaccination

rotavirus vaccine risk intussusception

The records of 583 children who were treated for intussusception at the Children's Hospital of Buffalo in the period 1930-1985 were reviewed. The children were followed up for one or two rotavirus epidemic seasons. As of 30 June 2018 the Centre for Adverse Reactions Monitoring had received 565 reports of suspected adverse reactions to rotavirus vaccine, in 11 cases the reaction was reported to be intussusception. The risk of intussusception appeared greatest 3—7 days after administration of the first vaccine dose. Study limitations included a lack of statistical power as a result of poor vaccine coverage rates and the potential for residual confounding. The peak incidence is in infants 5-10 months of age, with 80% of cases occurring before 24 months of age, and it is much more common in males than females. A structured literature review was used to identify studies that characterized morbidity rates by prospective surveillance of stable populations and studies that characterized mortality attributable to diarrhoea through active surveillance.

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Rotavirus Vaccine and Intussusception

rotavirus vaccine risk intussusception

Most episodes occur in otherwise healthy and well-nourished children. In nine cases the affected child was male. Causes Approximately 75 percent of intussusception cases are idiopathic as no clear disease trigger or lead point is found. Rotarix replaced RotaTeq on the Schedule in 2017. Ten-year review of intussusception at Starship Hospital: 1998—2007. It is estimated to occur each year in around 80 per 100,000 children under 12 months of age, which represents approximately 200 cases per year in Australia.

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Rotavirus vaccination and risk of intussusception

rotavirus vaccine risk intussusception

Also, it is thought that wild type rotavirus infections can also trigger intussusception, so the rotavirus vaccines might prevent those cases. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. A summary of the pre-licensing trials reported five cases of intussusception among 10,054 infants receiving vaccine and one case in 4,633 placebo patients 0. The result of animal experiment showed that the effect of gastrin and etiology of intussusception are identical. The most common germs were adenovirus, yersinia and staphylococcus aureus. As of January 31, 2007, 3. The findings with RotaRix are particularly instructive.

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Risk Factors for Infant Intussusception After Introduction of Rotavirus Vaccine

rotavirus vaccine risk intussusception

Because the incidence of natural rotavirus infections has decreased dramatically, we have essentially replaced natural rotavirus with vaccine viruses. Results were pooled using both fixed and random study effect model. At the time, it was hard to understand why RotaShield had caused this problem. Several approved oral vaccines have been developed, and several oral platform approaches are under investigation that might expand the available pool of vaccines. However, strict inclusion criteria were used to have a very specific endpoint and to avoid bias to the null hypothesis of absence of risk.

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