Rotavirus vaccine causes diarrhoea. Impact of rotavirus vaccine on all

Impact of rotavirus vaccine on all

rotavirus vaccine causes diarrhoea

The writer is head of paediatrics at St Stephens Hospital, Delhi and petitioner in the case against Rotavac. This is not the first time that rotavirus vaccine trials have courted controversy. This data suggests that while the incidence of diarrhoea caused by rotavirus comes down after vaccination, other viruses replace rotavirus as the cause of diarrhoea and ultimately there is an increase in the incidence of diarrhoea. The New England Journal of Medicine, which published the study, has this week published a written by a colleague and I in response to the original article, which points out that there was a significantly higher rate of gastroenteritis and diarrhoea in the vaccinated group compared to those given the placebo — an inert dummy vaccine. Recently, the internationally licensed rotavirus vaccine Rotarix manufactured by GlaxoSmithKline has also been mired in a similar controversy. According to a letter published in there were more cases of children reporting diarrhoea among the vaccinated although the difference was not statistically significant. The purpose of the vaccine is to reduce the incidence of diarrhoea.

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Impact of rotavirus vaccine on all

rotavirus vaccine causes diarrhoea

We welcome your comments at. Results Diarrhea hospitalizations decreased after rotavirus vaccine introduction. The vaccine was studied in clinical trials in Vellore, Delhi and Pune. In March, the New England Journal of Medicine published the results of a clinical trial of a rotavirus vaccine developed by the Serum Institute of India. . However, while those vaccinated had fewer episodes of rotavirus diarrhoea, diarrhoea caused by other agents increased significantly.

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A new rotavirus vaccine that causes more, not less, diarrhea

rotavirus vaccine causes diarrhoea

An anti-diarrhoea vaccine that increases the incidence of diarrhoea is unlikely to find a market. The paper highlighted that the vaccine reduced the incidence of rotavirus gastroenteritis and suggested that this new vaccine would be effective in controlling the disease. The latest studies quoted above seem to suggest that not only is efficacy against rotavirus infection low, the vaccine may be encouraging shifts in the viral strain and an increase in non-rotavirus diarrhoea. Rotavirus positivity paralleled patterns observed in diarrhea. Misrepresenting research findings, cherry picking data, and concealing adverse events in clinical trials have become more common and are almost unquestioned practices to this end. Conclusions Following rotavirus vaccine introduction all-cause diarrhea and rotavirus-specific hospitalizations declined dramatically. This highlights how cherry picked data gets published even in the most prestigious medical journals.

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A new rotavirus vaccine that causes more, not less, diarrhea

rotavirus vaccine causes diarrhoea

Patients seldom care about what virus or bacteria are causing their diarrhoea. Fortunately, the New England Journal of Medicine has now published a letter pointing out the discrepancy. Rotavirus is a virus that causes gastroenteritis and diarrhoea in babies and young children and is the leading cause of childhood diarrhoeal deaths around the world. Before vaccine introduction, 56% of stool specimens tested positive for rotavirus; the percent positive was 13% in 2015, 12% in 2016. Background Rotavirus vaccine was introduced into the Extended Program on Immunization in Madagascar in May 2014. This vaccine is licensed for use only in India. The efficacy of rotavirus vaccines is much lower in Asia at a mere 50% compared to 90% efficacy in the west.

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A new rotavirus vaccine that causes more, not less, diarrhea

rotavirus vaccine causes diarrhoea

What the paper tries to gloss over is data from the trial that shows that the overall incidence of diarrhoea among those who received the vaccine actually increased raising questions about how safe the vaccine really is. Data on a potentially fatal complication with use of the vaccine — intussusception, where the intestine telescopes into itself and can become gangrenous — has not been published despite repeated requests from various quarters. Adverse effects of Rotavac The third controversial rotavirus vaccine is Rotavac manufactured by Bharat Biotech in Hyderabad. The authors from France, the United States and Niger that vaccine efficacy was 66. The median proportion of annual hospitalizations due to diarrhea was 26% range: 31—22% before vaccine introduction; the proportion was 25% the year of vaccine introduction, 17% in 2015 and 16% in 2016. The lack of transparency of data in these three rotavirus vaccine cases boils down to the motives of making profits off the vaccines.

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Impact of rotavirus vaccine on all

rotavirus vaccine causes diarrhoea

This could prevent desperately poor countries like Niger from spending billions of dollars on a vaccine that increased diarrhoea instead of controlling it. . . . . . .

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