Rotavirus intussusception. Rotavirus Vaccine Linked to Serious Intestinal Disorder in Infants

Rotavirus vaccination and intussusception

rotavirus intussusception

In some high- and lower middle-income countries, rotavirus vaccination has been shown to reduce hospitalizations among children and adults who are too old to be vaccinated, an effect known as herd immunity. Furthermore, the intussusception risk in the 8 to 21-day period or 1 to 21-day period after either dose 1 or dose 2 was not found to be higher than the background risk. Postmarketing surveillance of intussusception following mass introduction of the attenuated human rotavirus vaccine in Mexico. . Some infectious agents, particularly respiratory adenoviruses and pathogens causing bacterial enteritis e. Herd immunity is likely related to reduction in community transmission of rotavirus because of vaccination.

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Rotavirus Vaccine Linked to Serious Intestinal Disorder in Infants

rotavirus intussusception

Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. The observation of mesenteric lymphadenopathy or inflamed Peyer's patches in a significant proportion of cases points to an inflammatory process. The third question raised by this vaccine experience is an ethical one. This workshop was a follow-up meeting of the 2011 intussusception meeting of technical and public health experts. Although comparison of reporting rates with baseline intussusception rates showed no increased risk during the 21-day period following vaccination, the clustering of cases during the first week following vaccination was noted and further monitoring was recommended. Real-time surveillance to assess risk of intussusception and other adverse events after pentavalent, bovine-derived rotavirus vaccine.

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No Association Between Rotavirus Vaccination and Intussusception in New Study

rotavirus intussusception

As of 1 May 2016, 81 countries, including 38 low-income countries eligible for support from Gavi, the Vaccine Alliance, have introduced these vaccines into their national immunization programs. Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program. Regarding potential mechanisms of intussusception, mouse models have demonstrated that, despite the induction of massive intestinal lymphoid hyperplasia following wild-type rotavirus infection, lymphoid hyperplasia is not required as a lead point for rotavirus-induced intussusception, and rotavirus infection does not directly alter intestinal motility to induce intussusception. An initial post-marketing surveillance study with a reporting period of 1 July 2007 to 31 December 2008 suggested an increased risk of intussusception in the dose 1 post-vaccination risk window. Reasons for regional variation are not well defined, but could relate to multiple factors including genetic predisposition, circulating pathogens, differences in feeding practices, and differences in diagnostic practices and access to health care.

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The link between rotavirus vaccination and intussusception: implications for vaccine strategies

rotavirus intussusception

Information on vaccinations was verified by the provider. Furthermore, well-designed post-licensure evaluations should be conducted in regionally representative countries that are also conducting impact evaluations of rotavirus vaccination. Of the 446 infants identified with intussusception, 429 were included in the study 96%. A 2011 study found the rotavirus vaccine prevented 65,000 U. Intussusception among infants given an oral rotavirus vaccine. Meeting objectives were to evaluate updated data, identify and prioritize research gaps, discuss best practices for intussusception monitoring in lower-income settings and risk communication, and provide insight to country-level stakeholders on best practices for intussusception monitoring and communication. Rotavirus vaccination status was confirmed by review of vaccine card or clinic records.

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The link between rotavirus vaccination and intussusception: implications for vaccine strategies

rotavirus intussusception

Acknowledgments We would like to thank all meeting participants, particularly the following individuals for their presentations and review of this report: Remon Abu-Elyazeed, Narendra K. Intussusception following rotavirus vaccine administration: post-marketing surveillance in the National Immunization Program in Australia. Preparing for safety monitoring after rotavirus vaccine implementation: a retrospective review of intussusception cases among children at a large teaching hospital in Rwanda, 2009-2012. In other words, discussion of the risks and benefits of rotavirus vaccination, not just risks, should always occur. There is little doubt of the worldwide need for an effective and safe rotavirus vaccine. After the first dose, 1 case occurred in the 1 to 7-day period after vaccination and 6 cases occurred in the 8 to 21-day period. Future priority activities for intussusception and rotavirus vaccines identified at this meeting were related to preparing for future vaccine introduction in lower-income settings of Africa and Asia, addressing gaps in knowledge, addressing and monitoring issues related to strict age recommendations, and developing key messages for communication about intussusception.

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No Association Between Rotavirus Vaccination and Intussusception in New Study

rotavirus intussusception

Indeed, the pathogenesis of intussusception in infants is poorly understood. Intussusception Intussusception is a rare condition in which the intestine folds in on itself. There was a smaller increased risk 1—7 d following dose 2 of each vaccine. Therefore, it is now time to document use, benefit, and safety of rotavirus vaccines in countries that have implemented the expanded age recommendations for rotavirus vaccine administration. After the second dose, 5 cases occurred in the 1 to 7 day-period after vaccination and 16 cases occurred in the 8 to 21-day period after vaccination. Information on the incidence of intussusception in this study population is not available. Many have documented significant declines in rotavirus-specific and all-cause diarrheal illnesses following vaccine introduction.

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Rotavirus vaccination and intussusception

rotavirus intussusception

Lessons learned from this experience included the following: 1 It is difficult to conduct a clinical trial large enough to detect such a rare adverse event; 2 well-designed post-licensure analytical observational studies are critical; and 3 recommendations should be based upon risk-benefit analyses for each region. Decline in diarrhea mortality and admissions after routine childhood rotavirus immunization in Brazil: a time-series analysis. Risk-benefit of rotavirus vaccination on rotavirus hospitalizations and deaths and associated intussusception risk for one vaccinated birth cohort to age 5 years, multiple countries. In addition, findings were similar for the 1 to 7-day period after dose 2 relative incidence, 0. In response to this signal, the Australian Therapeutic Goods Administration commissioned a national study to evaluate the risk of intussusception following rotavirus vaccination and to compare the vaccine-attributable risk of intussusception with the estimated reduction in gastroenteritis hospitalizations following vaccine introduction.

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