Risk of intussusception after monovalent rotavirus vaccination. (PDF) Evaluation of Intussusception After Oral Monovalent Rotavirus Vaccination in South Africa

Association Between Rotavirus Vaccination and Risk of Intussusception Among Neonates and Infants

risk of intussusception after monovalent rotavirus vaccination

Concept and design: Lu, Goyal, Xu. Analysis of the subtotal group of different vaccine types and the pooled estimated risks of intussusception within 31 days after each dose, and 1 and 2 years after vaccination revealed no association of risk of developing intussusception after receipt of the rotavirus vaccine, a finding that corresponds with the results of some previous studies. The incidence of intussusception varies considerably by region. Escolano S, Hill C, Tubert-Bitter P: A new self-controlled case series method for analyzing spontaneous reports of adverse events after vaccination. Vaccine 2004; 22: 569—74 25. Calculation of attributable risk Based on the age-specific annual background incidence of intussusceptions per 100 000 infants in Germany , the number of intussusceptions that would normally occur in a birth cohort in this case 2014 within the 7-day risk period was calculated. Lancet Infect Dis 2012; 12: 136—41 3.

Next

Risk of intussusception after monovalent rotavirus vaccination.

risk of intussusception after monovalent rotavirus vaccination

Acta Paediatr 2010; 99: 92. The full texts of the remaining 81 studies were reviewed in detail. Mean interval between onset and admission, and clinical features were similar between vaccine-associated and background cases. Conflict of interest statement The authors declare that no conflict of interest exists. Dr Xu had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The risk attributable to the vaccine was calculated by subtracting from this value the number of background cases occurring per week in the birth cohort.

Next

Risk of intussusception after monovalent rotavirus vaccination.

risk of intussusception after monovalent rotavirus vaccination

All controls were enrolled prospectively. The frequency and proportion of intussusception among overall surgical admissions, as well as the demographic and clinical information of the cases is described. This is much higher than the findings of Cortese et al in the United States, whose study showed that 4. Current health insurance company claim data indicate that 11. In addition, the risk of intussusception in the 8 to 21 days or 1 to 21 days after either dose was not found to be higher than the background risk. We identified 57 articles from 27 countries.

Next

Risk of intussusception after monovalent rotavirus vaccination.

risk of intussusception after monovalent rotavirus vaccination

Post—dose 1, there were zero intussusception cases within 1—7 days, and 5 cases within 8—21 days of vaccination. We evaluated trends in all-cause diarrheal hospitalizations in Soweto, Johannesburg, before and after the introduction of rotavirus vaccine into South Africa's national immunization program in August 2009. Retrospective case enrollment was done at 1 hospital from July 2012 through August 2013. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. Stowe J, Andrews N, Ladhani S, Miller E: The risk of intussusception following monovalent rotavirus vaccination in England: a self-controlled case-series evaluation.

Next

Intussusception After Monovalent Human Rotavirus Vaccine in... : The Pediatric Infectious Disease Journal

risk of intussusception after monovalent rotavirus vaccination

We identified 6 cases of intussusception within 7 days after the administration of either dose of vaccine. If the infant develops symptoms that might indicate intussusception during the 7 days after vaccination e. In African children, intussusception has been reported infrequently at a young age when the first dose of rotavirus vaccine is administered. Pediatrics 2008; 121: 1206—12 18. Results were similar for the case-control analysis.

Next

Evaluation of Intussusception After Oral Monovalent Rotavirus Vaccination in South Africa

risk of intussusception after monovalent rotavirus vaccination

Numbers of rotavirus gastroenteritis deaths and intussusception deaths in each week of age were calculated for all infants born in the year 2015 between birth and age 5·0 years, with and without restrictions on age at administration. The pooled effects were calculated using the fixed-effect model. For the two doses combined, the expected number of intussusception cases was 0. Vaccine proximate episodes occurred at a significantly younger age, which was not unexpected given the upper age limits for vaccination. Some studies included the participants from the same general population, in which case, the most comprehensive and up-to-date study was selected for inclusion in this meta-analysis.

Next