Mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2. Effective inhibition of MERS

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.

mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. During its first month, the recently emerged 2019 Wuhan novel coronavirus 2019-nCoV has already infected many thousands of people in mainland China and worldwide and took hundreds of lives. Oral Presentation O-097, 2016, 10 Suppl 1 : S42. Cells were harvested at 24 h after transfection for subsequent experiments. Researcher : List of Research Outputs , , , , , , , , , , , and , Relation of Tricuspid Regurgitation to Liver Stiffness Measured by Transient Elastography in Patients With Left-Sided Cardiac Valve Disease, The American Journal of Cardiology. Liu T, Zang N, Zhou N, Li W, Xie X, Deng Y, Ren L, Long X, Li S, Zhou L, et al. International Lupus Congress,Clin Exp Rheumatol 2015; 33 Supp 90 , , 2015, S-40.

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The role of laboratory diagnostics in emerging viral infections: the example of the Middle East respiratory syndrome epidemic

mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2

Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia. Rapid generation of a mouse model for Middle East respiratory syndrome. However, Smad7 can also inhibit renal fibrosis in animal models of chronic kidney disease. Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts. Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis.

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The development and application of Laboratory Animal Science in China

mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2

Funding: The Shaw Foundation Hong Kong, Michael Seak-Kan Tong, Respiratory Viral Research Foundation Limited, Hui Ming, Hui Hoy and Chow Sin Lan Charity Fund Limited, Marina Man-Wai Lee, the Hong Kong Hainan Commercial Association South China Microbiology Research Fund, Sanming Project of Medicine Shenzhen , and High Level-Hospital Program Guangdong Health Commission. Which animals are sensitive to new pathogens? Smad7 protein expression was quantified using ImageJ software version 1. Hong Kong Med J 2016. Lower respiratory infections remain one of the top global causes of death and the emergence of new diseases continues to be a concern. Here we investigated publicly available 2019-nCoV genome sequences for such evidence.

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Dept of Microbiology

mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. In this regard, coronaviruses have evolved a complicated receptor-recognition system through their spike proteins. Hong Kong Med J 2016. If a group shows up 95% of the time or more, the evidence for it is taken to be statistically significant. Consent for publication Not applicable.

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Department of Microbiology

mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2

The resource bank of susceptible animals with different pathogens has been established to solve the problem of timeliness in the establishment of animal models. . Researcher : List of Research Outputs and , Diabetic Nephropathy: Landmark: clinical trials and tribulations, Nephrol Dial Transplant. Cancer Res 2008; 68: 8976-85. One-way analysis of variance followed by the least significant difference test was used to analyze comparisons among multiple groups.

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Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study

mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2

First international external quality assessment of molecular diagnostics for Mers-CoV. J Hong Kong Coll Cardiol 2015. Embo Rep 2003; 4: 412-8. Under this guideline, in 2004, Prof. Mastromarino P, Capobianco D, Cannata F, Nardis C, Mattia E, De Leo A, Restignoli R, Francioso A, Mosca L.

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Effective inhibition of MERS

mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2

Infectious Middle East respiratory syndrome coronavirus excretion and serotype variability based on live virus isolates from patients in Saudi Arabia. International Lupus Congress, 2015, Clin Exp Rheumatol 2015;33 Supp 90 , 2015, S-40. The branch lengths as well as the topology of a parsimonious tree can quickly be obtained by using this method. Although we perhaps most frequently think of viruses when discussing emerging respiratory infections, bacteria have not been left out of the mix, as we have witnessed an increase in the number of infections from Legionella spp. Resveratrol showed antiviral activity against chikungunya infection. One family cluster was found.

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